BFS Machine Aseptic Blow-Fill-Seal System

Characteristics

1．The design, MOC, manufacturing, assembly, and debugging of the Pharmaceutical Aseptic Blow Fill Seal BFS system meet the requirements of the new GMP standards for drug production.

2．Advanced equipment, unique and reasonable structure, stable and reliable performance.

3．Applicable Specification: 0.2ml-1000ml plastic bottle (as per user’s requirements).

4．Production Capacity: 1000-18000BPH for Pharmaceutical Aseptic Blow Fill Seal BFS system

5．The number of bottles made each time: 1-30 bottles/mold, can be selected based on production capacity.

6．Filling Accuracy: ≤ ±1% (according to drug characteristics)

7．The BFS machine is integrated with bottle-making, filling, and sealing, with compact structure and occupies a small area, which reduces clean workshop area and saves energy consumption of air conditioning unit, as well as investment and use cost.

8．The plastic particles are plasticized by a low-speed long screw extruder driven by a specially designed servo motor, which can effectively reduce thermal stress of the material and accurately control the size of bottle preforms.

9．Each working cycle of the equipment can be compared and controlled automatically, with real-time feedback.

10．Stainless steel 304 hopper at extrusion station of the equipment is equipped with a level switch and linked with feeding device; when the material level is getting lowered, the alarm information of “lack of material” will be displayed on the man-machine interface.

11．High production efficiency, stable product performance, simple and reliable operation, and beautiful appearance.

12．For large capacity products, the container thickness is controlled at 100 points by an advanced thickness controller, and the precision servo motor controls the gap between mold core and mold cup.

13．The filling system is accurately calculated by time pressure method with high filling precision, which can meet the filling range of 0.2ml-2000ml to ensure production speed.

14．The equipment has black and white sections, the moving parts are isolated in non-clean are(black area), and only the basic components and operations are kept in the clean area(white area), which reduces the area of cleanroom and the number of particles in cleanroom.

15．Automatic in-place cleaning / in-place sterilization function (CIP/SIP) can be realized.

16．Configurable on-line monitoring system for dust particles and plankton bacteria.

17．In the process of bottle transfer, the inner surface of the interface is not in contact with parts, which eliminates the production of visible foreign matter.

18．To realize fully automatic control and monitor of the production process, high precision color touch screen operation monitoring, PLC automatic control, automatic protection, host frequency conversion speed regulation, and other control technology is used.

19．The products can be customized according to the actual demand of customers.